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University of Michigan Health System tests beating heart transplants

Despite advances in organ transplantation, the way donor hearts are moved from hospital to hospital remains low-tech:  stored on ice and carried in a store-bought cooler.

University of Michigan Frankel Cardiovascular Center’s Dr. Ashraf Abou El Ela, a cardiac surgeon and perfusionist Michael Aquino, review use of high-tech heart box for transplant. The University of Michigan Health System is testing a new high-tech heart box that circulates blood from the donor to the heart so that it continues throbbing while in transit.

Conventional methods allow a heart to be viable for around four hours before it has to be discarded. Using the investigational Transmedics Organ Care System (OCS), the heart is kept beating outside the body, warm and pumping even before doctors transplant it.

“With this method of transplantation, hearts are kept beating, allowing for organs to be transplanted longer distances so that more opportunities may arise for our patients to receive the organs they desperately need,” says study principal investigator Francis D. Pagani, M.D., Ph.D., a cardiac surgeon at the University of Michigan Frankel Cardiovascular Center.

“It has the potential to transform the way we do heart transplantation in this country,” he says. The experimental operation that’s mostly been done in Europe is now being tested in the United States where 4,000 people are waiting for a new heart.

The University of Michigan is one of 12 centers participating in the EXPAND clinical trial that will test whether the OCS is as effective as the current method of storing the heart on ice. The OCS Heart system will perfuse the heart with oxygen and nutrients during transport and keep the donor heart functioning and beating at normal body temperature.

Transplant and organ recovery teams are preparing for Michigan’s first case, including practicing transporting the device on the U-M’s Survival Flight aircraft which is used to rush organs to patients in need.

By using the OCS many more donor hearts may be able to be transplanted because of the prolonged time they are viable outside of the body. Hearts will now be able to travel longer distances, allowing for more potential recipients. Also because the organ is kept beating, this allows surgeons to get a more comprehensive look at the heart before transplant. Learn more about the study at

Article republished here with permission. Original article by U-M Health System.

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